POSITION SUMMARY:  We are seeking a highly motivated individual to join a dynamic research team in the area of stem cell biology and immunology.  The Research Associate will conduct cell culture experiments with stem cell- and primary tissue-derived cell populations, and closely interact with other lab members to design and execute projects. The individual will learn and apply molecular biology and immunology techniques on models of development and immune diseases.  The ideal candidate will have a strong background in immunology, cell culture or molecular biology.

Castilla Lab. Our laboratory studies the formation of blood cancers, such as leukemias, and how to use these discoveries to design novel therapies.  We combine genomic, pharmacology and functional approaches in animal models and patient samples to define key cellular pathways that govern leukemia stem cell survival a drug resistance. We have used a variety of molecular techniques, including CRISPR/Cas9 gene editing, RNA-sequencing and single cell RNA sequencing, ChIP-seq, CUT&RUN, 5C, and ATAC-seq, to define key drivers of cancer progression. For example, we have used these techniques to demonstrate that expression of the MYC master oncogene can be regulated by the leukemia oncoprotein CBFb-SMMHC by coopting regulation of the myeloid MYC distal enhancer in blood stem cells. To translate these findings to novel therapies, we have characterized  candidate targeted therapies for CBFb-SMMHC leukemia, some of which are in preclinical studies. We continue collaborating with a multidisciplinary research group to improve the “druggability” of these inhibitors in animal models and cells, and bring the new drugs to the clinic. We are looking for motivated and dependable candidates with background in biology and chemistry fields who can learn new protocols and work with our team to discover new cancer pathways and develop new targeted therapies to treat or prevent cancer.    

  Opportunity Postdoctoral Research Fellow in the Pukkila-Worley Laboratory Salary NIH postdoctoral pay scale (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-21-049.html)   Location Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School Job Description We are seeking a highly motivated and creative individual to join us in investigating conserved mechanisms of host-pathogen interactions in the intestine. Specifically, our lab focuses on three broad questions: - How are bacteria sensed by the innate immune system? This project [R01 AI130289: funding period 2017-2027], the renewal of which received a score in the 2nd percentile (March 2022), focuses on characterizing the role of a specialized type of transcription factor called nuclear hormone receptors in the sensing of metabolites derived from a pathogenic bacteria during infection — a totally new mechanism of pathogen sensing and immune activation. - How does metabolism affect the ability of a host to survive infection? Funded by a new R01 award [R01 AI159159: funding period 2021-2026], which received a score in the 1st percentile in June 2021, we are defining the links between energy sufficiency and the activation of protective immune defenses that are essential to survive infection. Specifically, this project dives into the mechanics of the p38 MAP kinase innate immune pathway to figure out how protective immune defenses are activated in response to pathogen-induced changes in host metabolism - How do neurons control inflammation in the intestine? Under a newly funded R21 [R21 AI163430: funding period 2021-2023], we are characterizing sensory neurons that regulate intestinal immune responses — a window into so-called gut-brain-microbiome axis that is not well understood, but is essential for innate immune homeostasis. Applicants with expertise in any area of science will be considered. Expertise in molecular biology, cell biology and genetics in any model system, in particular C. elegans, Drosophila or mice, is a bonus.  Specific Requirements - A Ph.D. or M.D. (or equivalent) - Evidence of previous scientific scholarship, specifically the publication of original research articles in peer reviewed journals as first author - The candidate must also be responsible, have strong communication and interpersonal skills and be willing to work in a highly collaborative and open research environment. Application Materials - A cover letter explaining your scientific background and your reasons for wanting to join our group - A curriculum vitae (with publication list) - Three letters of reference will be needed upon request Application Method Please apply by email to the Principal Investigator: Read Pukkila-Worley, M.D. (RPWlab@gmail.com, @RPWlab) For more information, please visit our lab website (http://www.umassmed.edu/pukkila-worleylab)      

The Bosco laboratory at the University of Massachusetts Chan Medical School (https://www.umassmed.edu/umasschan/) has an open position for a Post-Doctoral Fellow. Our laboratory is highly interdisciplinary and collaborative. We are located in the state-of-the-art Albert Sherman Center for translational science at the University Campus in Worcester, MA, which is about 1 hour from both Boston, MA and Providence, RI. Our research focuses on molecular mechanisms underlying neurodegeneration, with a focus on amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Our model systems include mouse models and cells (e.g., neurons and microglia) derived from human induced pluripotent stem cells (iPSCs). Our lab also utilizes biochemical and biophysical approaches to understand how disease-causing mutations affect protein structure and function at the molecular level. Members are welcome to work with various models, or to focus on one.   Relevant recent publications from our lab: Lin, et al, Nature Neuroscience, 2021 (https://pubmed.ncbi.nlm.nih.gov/34059832/) Schmidt, et al, PNAS, 2021 (https://pubmed.ncbi.nlm.nih.gov/34074767/)   Please visit our website for a list of publications and descriptions of ongoing projects (https://www.boscolab.com/). Applications from outside the US are welcomed.   Preferred qualifications: Experience working with molecular biology, including RNA/DNA processing, sterile-culture techniques and/or animal handling.   Eligibility: The candidate will have a PhD and/or MD degree with prior experience in the biological or physical sciences.   Contact Information: To apply, please send your cover letter and CV to Daryl.Bosco@umassmed.edu.

GENERAL SUMMARY OF POSITION:  Under the direction of the Associate Vice Chancellor/Director or designee, the Administrative Coordinator performs complex and varied duties associated with the coordination of departmental administrative functions.

GENERAL SUMMARY OF POSITION:     Under the general direction of the Principal Investigator or designee, the Research Associate IV performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.    

GENERAL SUMMARY OF POSITION:     Under the general direction of the Principal Investigator or designee, the Research Associate IV performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.    

GENERAL SUMMARY OF POSITION: Under the supervision of the Veterinary Services Supervisor or designee, provides clinical and laboratory support in the research animal facilities including specimen collection, treatments, assisting with rodent breeding colony management, animal health rounds and some surgical assistance. This position is considered essential, and as such requires weekend, holiday, and off hours coverage as needed and/or on a rotating basis.    

POSITION SUMMARY:    The Bosco laboratory at the University of Massachusetts Chan Medical School has an open position for a Research Associate. Our laboratory is highly interdisciplinary and collaborative (www.boscolab.com). We are located in the state-of-the-art Albert Sherman Center for translational science at the University Campus in Worcester, MA. Our research focuses on molecular mechanisms underlying neurodegeneration, with a focus on amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Our model systems include mouse models and cells (e.g., neurons and microglia) derived from human induced pluripotent stem cells (iPSCs). Our lab also utilizes biochemical and biophysical approaches to understand how disease-causing mutations affect protein structure and function at the molecular level.   Under the direction of the Principal Investigator or Designee, the Research Associate I performs a variety of complex research experiments.    

Postdoctoral Associate, Lab of Viral Replication, Pathogenesis, and Immunity, UMass Medical School   Candidates are invited to apply for a post-doctoral position to study pathogenic viruses, including SARS-CoV-2, Ebola virus, and HIV-1. Research topics include basic mechanisms of virus replication, interaction between the virus and host factors, virus evolution, innate immune detection, gene function and chromatin profiling in primary human immune cells. Please see recent publications at: https://pubmed.ncbi.nlm.nih.gov/?term=luban+j&sort=date   Qualifications: Education, experience and skills required for consideration:   - Ph.D. in biochemistry, molecular biology, immunology, virology, or bioinformatics, or M.D. with equivalent experience - Evidence of creativity and excitement about applying skills towards solving biological problems - Highly collegial, works well as a team member, and embraces diversity as an essential strength of research - Excellent analytical skills and independent judgement - Strong written and verbal communication skills - Meticulous record keeping, proficiency with databases, and computational skills   To Apply:   Applicants should submit the following materials by email to Dr. Jeremy Luban at jeremy.luban@umassmed.edu: a letter describing current research activities and your interest in this position, a CV (including a complete list of publications), and contact information for three references, one of which should be your Ph.D. advisor. We encourage all qualified applicants to apply. Diversity is a core value of our campus, the only public medical school in the Commonwealth of Massachusetts.

GENERAL SUMMARY OF POSITION:  Under the direction of the mental health nurse manager, functions as a professional by utilizing the nursing process in caring for psychiatric patients. Is responsible for incorporating general and unit specific competencies into nursing practice.  Adheres to UMMC nursing standards in accordance with licensure of Registered Nurses by the Commonwealth of Massachusetts.     

GENERAL SUMMARY OF POSITION:    Under the direct supervision of a Principal Investigator or designee, the Research Lab Tech II performs and interprets routine and highly complex experiments.  

GENERAL SUMMARY OF POSITION:  Under the supervision of the Principal Investigator or designee, the Research Laboratory Technician I, performs a variety of specimen preparatory techniques, dry lab data collection, and routine laboratory maintenance.    

GENERAL SUMMARY OF POSITION:  Under the general supervision of the nurse manager or designee, participates as a member of the mental health team on an inpatient Mental Health Unit.  Provides direct patient care including; treatment planning, implementing plans, evaluating treatment, discharge planning, and milieu activities.  

GENERAL SUMMARY OF POSITION:  Under the general supervision of the Principal Investigator or designee, the Nurse Practitioneras a member of research team is responsible for independently carrying out multiple complex research protocol designed to test the efficacy of a behavioral intervention; select and monitor test populations; provide expert consultation to clinical research staff; collect and help analyze data; report findings to principal investigator, and IRB when necessary. 

GENERAL SUMMARY OF POSITION: Under the supervision of the Veterinary Services Supervisor or designee, provides clinical and laboratory support in the research animal facilities including specimen collection, treatments, assisting with rodent breeding colony management, animal health rounds and some surgical assistance. This position is considered essential, and as such requires weekend, holiday, and off hours coverage as needed and/or on a rotating basis.    

GENERAL SUMMARY OF POSITION: Under the general direction of the Manager or designee, the System Administration Engineer II is a technical specialist role in the System Administration area supporting network operating systems in a multiple platform environment.

POSITION SUMMARY: Under the general direction of the director or designee, the Animal Operations Coordinator will direct all work order and project management in the animal research facilities.  The position is considered essential, and as such requires weekend, holiday and off hour’s coverage as needed.

POSITION SUMMARY:  Under general supervision of the Associate Director, Animal Care & Facilities or designee, the Animal Care and Facilities Manager manages the day-to-day operations of all animal husbandry and care activities.  The Animal Care & Facilities Manager is responsible for managing the husbandry and animal care activities in a major research animal program.  

GENERAL SUMMARY OF POSITION:   The Donahue lab develops gene therapy for cardiac arrhythmias.  The main focus of the lab is to conquer atrial fibrillation and ventricular tachycardia.   We work with animal models, and we are developing gene therapy clinical trials. This position will support the lab in our efforts by using patch clamp analysis to help define mechanism of the arrhythmias under study and to assess changes with the gene therapies. The successful candidate must have a working knowledge of cardiac myocyte cell isolation and patch clamp techniques.    Under the general direction of the Principle Investigator, the Senior Research Scientist performs a variety of complex research experiments laboratory research on topics pertinent to the interests of the research programs of the laboratory.