Development of novel ZFP-based gene therapy approaches for monogenic disorders.   The Wolfe laboratory will be filling a postdoctoral position to develop new gene therapy reagents for the treatment of monogenic disorders in collaboration with other laboratories within UMMS. These efforts will focus on the creation of novel Cys2His2 zinc finger protein-based therapeutics for delivery to affected cell types.  This project will focus on:   1) The development of Cys2His2 zinc finger proteins (ZFPs) with novel DNA binding specificity to target specific (therapeutic) genomic loci.   2) The application of these ZFPs in cell culture and in vivo models of disease to abrogate disease-associated phenotypes.     These studies will expose the successful candidate to cutting-edge ZFP design and selection approaches, as well as in vitro and in vivo delivery approachs.  The successful candidate will also learn cutting edge deep-sequencing approaches to monitor the genome-wide binding locations and impact of the ZFPs on the genome and transcriptome. The successful candidate will have the opportunity to participate in meetings/conferences associated with gene therapy, which will broaden their exposure to cutting edge research within the field. In addition, the successful candidate will be exposed to CRISPR-Cas9 and CRISPR-Cas12a nuclease technologies that are being developed in the Wolfe laboratory. Candidates should have a Ph.D. in biology, biochemistry, chemistry or a related biomedical science. In addition, the potential candidate must have strong oral and written communication skills and be eager to present research results at national meetings. Prior experience with Cys2His2 zinc finger proteins, cell culture, and deep-sequencing technologies is advantageous, but not required.   Applicants should send a letter (via email) describing their current research activities and their interest in this position, a CV (including publications) and contact information for three references, including your Ph.D. advisor.   Address letters to Scot Wolfe (scot.wolfe@umassmed.edu). University of Massachusetts Medical School Department of Molecular, Cell and Cancer Biology 364 Plantation Street, LRB Room 619 Worcester, MA 01605   Further details about the Wolfe laboratory and the positions that are available can be found at https://www.umassmed.edu/Wolfe-Lab/ https://profiles.umassmed.edu/display/133161   UMass Medical School is committed to being an equal opportunity and affirmative action employer and recognizes the power of a diverse community. We encourage applications from protected veterans, individuals with disabilities and those with varied experiences, perspectives and backgrounds to consider UMass Medical School as their employer of choice.

The Kelliher lab has postdoctoral training positions available in the laboratory focused on NOTCH1- mediated leukemogenesis. We applied single cell and bulk RNA-seq to our mouse models of T cell acute lymphoblastic leukemia (T-ALL) to uncover the clonal heterogeneity that underlies leukemic progression and therapeutic resistance and relapse. These studies revealed a dormant DN3 thymic progenitor population with a gene expression signature that was shared with ALL patients experiencing minimal residual disease. A postdoctoral position is available to identify critical L-IC genes that mediate therapeutic resistance and relapse. Experience in hematopoiesis research preferred.   The Kelliher lab also has had a long standing interest in TNF signaling with a focus on the death domain kinase RIPK1. A postdoctoral fellow position is available to study contributions of RIPK- mediated cell death and/or proinflammatory signaling to human diseases including bone marrow failure, autoimmune hepatitis and neurodegenerative diseases. Experience in innate or adaptive immunology preferred.  For further information, please send cover letter, current CV and the names and contact information of three references to:Michelle Kelliher, PhD, Professor at Michelle.Kelliher@umassmed.edu

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or designee, the Research Associate I performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or Designee, the Research Associate performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION:  Under the direction of the Principal Investigator or designee, the Research Nurse Coordinator I is responsible to carry out all delegated tasks related to complex protocols testing investigational drugs, devices, or research interventions. The Research Nurse Coordinator I is a primary resource for study protocol conduct acting as a liaison between the University of Massachusetts Medical School (UMMS), clinical partners (ex. University of Massachusetts Memorial Health Care (UMMHC)), the Principal Investigator, Institutional Review Board (IRB), and sponsors to ensure good clinical practice standards (GCP) throughout the life cycle of the study.    

GENERAL SUMMARY OF POSITION:  Under the supervision of the Principal Investigator or designee, the Clinical Research Assistant is responsible for performing delegated tasks and procedures involving human subjects in support of  clinical research protocols. 

GENERAL SUMMARY OF POSITION: The Customer Services Technician I is an emerging role in the customer services area, field user telephone calls for Information Services support, provide assistance where possible, gather information for problem escalation.  

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or designee, the Research Associate I performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION:   Under the direction of the Residency Program Director, the Residency Program Administrator II provides operational management of the core residency program including recruitment, on-boarding, orientation, evaluation systems, data management and program accreditation.  The Administrator implements and coordinates personnel and regulatory procedures for incoming, continuing and graduating residents.

GENERAL SUMMARY OF POSITION: Under the direction of the Principal Investigator or designee, the Research Coordinator I is responsible for carrying out multiple complex research protocols.    

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

A postdoctoral position is available in the Benanti Lab at the University of Massachusetts Medical School to study the molecular mechanisms that regulate cell growth and division. The Benanti Lab is located in Department of Molecular, Cell and Cancer Biology where postdocs benefit from a modern open lab space with highly interactive colleagues, extensive bioinformatics support, and access to cutting-edge technologies.    The Benanti Lab utilizes molecular, genetic, and systems biology approaches to study cell cycle regulation in both yeast and human cells. Current projects include, but are not limited to: understanding how the cell cycle-regulatory network is rewired in response to environmental stress, investigating how phosphorylation regulates protein function, and identifying targets of ubiquitin ligases and deubiquitinating enzymes whose functions impact the cell cycle. For mor information see: https://umassmed.edu/benantilab/   Candidates should be highly motivated and technically accomplished, as documented by a strong publication record, and hold a recent Ph.D. in cell biology, molecular biology, genetics or related area of study. Ideal candidates will have demonstrated experience in genetics and advanced molecular biology approaches.   To apply, please send an email describing your current research activities and future research interests, a CV, and names and contact information for three references to Jennifer Benanti at: jennifer.benanti@umassmed.edu   Jennifer Benanti, Ph.D. Associate Professor Department of Molecular, Cell and Cancer Biology University of Massachusetts Medical School 364 Plantation St., LRB 525 Worcester, MA 01605  

POSITION SUMMARY:  Under the general direction of the Nurse Manager or designee, the Nurse Practitioner performs a variety of duties involving clinical healthcare, education, and research activities for the patient population at the Worcester State University Student Health Center.   This is a per diem role.  

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or Designee, the Research Associate performs a variety of complex research experiments.    

POSITION SUMMARY: Under the general supervision of the Manager, or designee, the Healthcare Data Analyst - MHE will perform basic data analyses and is responsible for data mining as required by the program. The Healthcare Data Analyst - MHE will also produce standard data analyses of healthcare claims and related data and produces all standard reports required by the client and/or program.

POSITION SUMMARY:  Under the direction of the Manager or designee, the Instructional Technologist III functions in all phases of instructional technology design and implementation, including the analysis of customer needs, technology and curriculum design, review, programming and implementation of information technology projects which relate to the educational missions of the University. Communicates well with faculty, students and staff through all phases of development and support. Performs duties in a manner consistent with a complex, diverse, dynamic hardware and software environment that serves a complex medical/education community. This position requires an experienced instructional technologist that is in touch with new trends and is very familiar with rapid development. The position requires individuals to be detail oriented, organized, independent, responsible and accountable.

A postdoctoral position is available in the McCollum lab. Work in the lab will be in cellular and molecular biology with a focus on analysis of the role of the Hippo signaling pathway in controlling cell proliferation in response to mechanical and cell cycle cues. Work in the lab is inherently multi-disciplinary and may include culture of multiple cell lines, protein purification and analysis, molecular cloning, CRISPR mutagenesis, and cell imaging. - Applicants must have (or expect to obtain shortly) a Ph.D. in Biochemistry, Cell Biology, Genetics, Molecular Biology, or related fields. - Applicants should have experience in several of the following areas: molecular cloning, protein expression, mutagenesis, cell culture, imaging, immunofluorescence, biochemistry.   TO APPLY: Please email CV, cover letter and contact information for three references to: dannel.mccollum@umassmed.edu

GENERAL SUMMARY OF POSITION:  Under the supervision of the Principal Investigator or designee, the Research Laboratory Technician I, performs a variety of specimen preparatory techniques, dry lab data collection, and routine laboratory maintenance.    

GENERAL SUMMARY OF POSITION: Under the general direction of the Principal Investigator or designee, the Research Project Director is responsible for coordinating the daily operations of research studies.    

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or designee, the Research Associate I performs a variety of complex research experiments.