We are inviting applications for postdoctoral positions to pursue multiple research topics that encompass gene therapy using AAV vectors, RNA therapy, virology, and AAV vector development. Applicants should have a PhD degree or an MD in relevant areas such as Molecular Biology, RNA biology, Biochemistry, Gene Therapy, Cell Therapy, Bioengineering, Neuromuscular Biology, Cell Biology, and Virology. Applicants with backgrounds in molecular cloning, mouse work, NHP work, microscopy, human and mouse genetics, bioinformatics, single-cell sequencing, or protein/structural biology are preferred.  Applicants must also can work independently and coordinate multiple projects, concurrently. Strong writing, verbal, and interpersonal skills are required.   Candidates should be highly organized, hard-working, and motivated to respond to changes within the rapidly evolving field of gene therapy. We offer excellent training opportunities and a competitive salary depending on experience and track record. If you have any of the above attributes and skill sets, and believe you are a good fit for our research program. To apply:  Please submit a cover letter and CV by email to Jun Xie at Jun.Xie@umassmed.edu

GENERAL SUMMARY OF POSITION:  The Bioinformatician III - Statistical Geneticist is independently responsible for statistical genetic analyses of large-scale human genetic datasets. Will perform analyses of human genotyping and sequencing data and conduct meta-analyses of multiple datasets as well as genetic-epidemiologic analyses. Individual will submit publications in peer reviewed journals, present at scientific meetings, and grow in the academic environment.

GENERAL SUMMARY OF POSITION:  Under the general direction of the Principal Investigator or designee, the Research Program Manager I is responsible for managing the day-to-day operations of NIH or other externally funded, large scale projects. The Research Program Manager will collaborate with investigators, consultants, project directors, and contract officers at the university, commonwealth, and national levels.    

POSITION SUMMARY:  We are seeking a Research Associate to work collaboratively on CRISPR-Cas gene editing of the Huntington’s Disease (HD) gene. HD is a devasting neurodegenerative disease that currently has no effective treatment. Our goal is to develop gene editing methods to inactivate or correct the disease-causing version of the gene at the DNA level. We are looking for ambitious, hardworking candidates to join this exciting project. There will be opportunities to become familiar with the molecular technologies in gene editing and NextGen sequencing as well as preclinical studies in cell culture and animal models. For an example of a recent study from the lab see https://pubmed.ncbi.nlm.nih.gov/34376056/.    

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

We are seeking a post-doctoral fellow to work on CRISPR-Cas gene editing of the Huntington’s Disease (HD) gene in collaboration with the labs of Neil Aronin and Scot Wolfe at UMass Chan. HD is a devasting neurodegenerative disease that has no effective treatment. We are developing novel gene editing approaches to inactivate or correct the CAG repeat expansion that causes HD. These studies implement cutting edge gene editing and NGS methods as well as preclinical studies in cell culture and animal models. The methods developed for HD may be applicable to a series of genetic disorders causes by expansion of short tandem repeat sequences. For an example of a recent study from the lab see https://pubmed.ncbi.nlm.nih.gov/34376056/ Send c.v. and contact information for 3 references to: Michael Brodsky at Michael.Brodsky@umassmed.edu

GENERAL SUMMARY OF POSITION:  Under the direction of the mental health nurse manager, functions as a professional by utilizing the nursing process in caring for psychiatric patients. Is responsible for incorporating general and unit specific competencies into nursing practice.  Adheres to UMMC nursing standards in accordance with licensure of Registered Nurses by the Commonwealth of Massachusetts.     

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

GENERAL SUMMARY OF POSITION:  Under the supervision of the Principal Investigator or designee, the Research Laboratory Technician I, performs a variety of specimen preparatory techniques, dry lab data collection, and routine laboratory maintenance.   Shaoguang Li, MD, PhD, has been working on understanding the biology of leukemia stem cells (LSCs) with a goal of developing more effective therapeutic strategies for leukemias. Recently, he has expanded his research into a new area: artificial intelligence (AI) in medicine. Specifically, his lab has developed unique algorithms for medical research, including, for example, the diagnosis of human lymphoma with high accuracy by reading pathological slides (Li D, Bledsoe JR, Zeng Y, Liu W, Hu Y, Bi K, Liang A, Li S. A deep learning diagnostic platform for diffuse large B-cell lymphoma with high accuracy across multiple hospitals. Nature Communications. 11(1):6004, 2020). He plans to further use the AI models established in his lab for studying molecular mechanisms underlying leukemogenesis and improving diagnostic accuracy of leukemias and solid tumors.

GENERAL SUMMARY OF POSITION:     We are seeking a Research Technician to work collaboratively on CRISPR-Cas gene editing of the Huntington’s Disease (HD) gene. HD is adevasting neurodegenerative disease that currently has no effective treatment. Our goal is to develop gene editing methods to inactivate orcorrect the disease-causing version of the gene at the DNA level. We are looking for ambitious, hardworking candidates to join this excitingproject. There will be opportunities to become familiar with the molecular technologies in gene editing and NextGen sequencing as well aspreclinical studies in cell culture and animal models. For an example of a recent study from the labsee https://pubmed.ncbi.nlm.nih.gov/34376056/SUPERVISION RECEIVED:    

The University of Massachusetts Chan Medical School - Application Deadline: Open Until Filled Job Description Postdoctoral Associate in Molecular Neurobiology A postdoctoral associate position is available in the Richter Lab for a highly motivated candidate with a PhD in molecular biology. neurobiology, or a related discipline. The Richter Lab is part of a vibrant research environment of the Program in Molecular Medicine at the University of Massachusetts Chan Medical School and is highly collaborative with other labs within and external to UMMS. Work in the lab focuses on understanding the molecular basis of learning and memory, particularly as it relates to neurodevelopmental disorders including Fragile X Syndrome and autism. The selected candidate will apply a combination of up-to-the-minute molecular techniques to assess mRNA translation and splicing regulation in mouse models of Fragile X Syndrome as well as in human iPSC-derived neurons. The lab performs several types of RNA-seq and ChIP-seq, ribosome profiling, RNA-protein interaction analysis, mouse behavior, neuronal cultures, etc. We are developing new methods to mitigate Fragile X Syndrome. This project provides an excellent opportunity to learn and further develop a variety of techniques. The selected candidate will work independently to design and execute experiments.  Results of this project will be presented at seminars and scientific meetings, which may involve travel. The post-doctoral fellow will also prepare and submit manuscripts.   Qualifications: Education, experience and skills required for consideration: - Ph. D. in molecular biology, neurobiology, or related disciplines - Strong work ethic, highly motivated to apply skills towards solving biological problems - Excellent analytical skills and independent judgement - Highly collegial and works well as a team member - Strong written and verbal communication skills; ability to communicate with precision and tact - Meticulous record keeping, proficiency with databases - Relevant references: Shah et al (2020) Cell Reports 30:4459; Shu et al (2020) PNAS 117:30400; Liu et al (2018) PNAS 115:E11397. To Apply:   Applicants should submit the following materials by email to Joel.Richter@umassmed.edu:  a letter describing current research activities and your interest in this position, a CV (including publications), and contact information for three references, one of which should be your Ph.D. advisor.

POSITION SUMMARY:  Under the direction of the Deputy Managing Director, Solutions Engineering and Operations the Senior Manager, IT Operations is responsible for managing all technology services used to enable business capabilities and services across the enterprise. The Senior Manager develops and maintains an understanding of the needs of the organization for performant and resilient infrastructure services and provides services in accordance with these needs.

GENERAL SUMMARY OF POSITION:  Under the direction of the Lead Custodian and Unit Director, performs general janitorial and custodial work in connection with the cleaning and maintenance of the Worcester Recovery Center and Hospital Adolescent Psychiatry Continuing Care Unit.  Will perform other related work as needed or required.    

GENERAL SUMMARY OF POSITION:   We are seeking a Research Associate to work collaboratively on CRISPR-Cas gene editing of the Huntington’s Disease (HD) gene. HD is a devasting neurodegenerative disease that currently has no effective treatment. Our goal is to develop gene editing methods to inactivate or correct the disease-causing version of the gene at the DNA level. We are looking for ambitious, hardworking candidates to join this exciting project. There will be opportunities to become familiar with the molecular technologies in gene editing and NextGen sequencing  as well as preclinical studies in cell culture and animal models. For an example of a recent study from the lab see https://pubmed.ncbi.nlm.nih.gov/34376056/   Preferred Qualifications: Some experience with Molecular Biology, Cell culture or mouse studies is preferred, but not essential    

GENERAL SUMMARY OF POSITION:     The Research Associate IV will join Dr. Neil Silverman’s active research group focused on innate immunity, using both vertebrate and invertebrate model systems.  The hire will be responsible for managing animal colonies and the general lab organization (~50% effort). It will also be directly involved in experiments independently or in support of senior lab members, depending on their goals (~50% effort).    Under the general direction of the Principal Investigator or designee, the Research Associate II performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.    

POSITION SUMMARY:  Under the direction of the Principal Investigator or Designee, the Research Associate - Flow Cytometry performs a variety of complex research experiments. A key responsibility for this position is the ability to design multiparameter flow cytometry panel and analyze the data.

GENERAL SUMMARY OF POSITION:     Under the general direction of the Principal Investigator or designee, the Research Associate IV performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.