The Brown Lab at the University of Massachusetts Chan Medical School (https://www.umassmed.edu/brownlab/) has immediate post-doctoral positions open in gene modulation therapy for ALS and related neurodegenerative diseases.  As one component of a new “Accelerator Initiative”( https://www.umassmed.edu/news/news-archives/2022/02/umass-alumni-dan-and-diane-riccio-pledge-$15-million-to-advance-als-neuroscience-research/), we are pursuing several approaches to modifying adverse gene variants that are implicated in both familial and sporadic ALS.  These include gene suppression (e.g. antisense oligonucleotides activating RNAse H), gene augmentation (small activating RNAs), and gene editing (e.g. gene editing, base editing, splice modification).  This program entails a productive, close collaboration with Jonathan Watts and Anastasia Khvorova in the UMass Chan RNA Therapeutics Institute.  This program is built upon our recent pilot human studies in suppression of two ALS genes, SOD1 (PMID 32640133) and C9orf72 (PMID 34949835). Our explicit goal is to transition rapidly from pre-clinical studies to pilot human studies for several other ALS genes.  It is our hope that the approaches developed in this program will be broadly applicable to a wide variety of human disorders. Preferred qualifications: - D. in Neuroscience, Biochemistry and Molecular Biology, or Related Discipline. - Skilled in conventional molecular methods such as quantitative methods for qualitative and quantitative analysis of gene expression (qPCR, ddPCR, Southern, Northern and Western blotting), gene cloning; - Experience culturing neurogenic cell lines; - Some experience in culturing and differentiation of human iPSC is desirable, but not an absolute prerequisite; - Analogously for generation of key sequences for therapeutic oligonucleic acids; understanding aspects of oligonucleic acid synthesis and purification; - Some experience with animal therapy trials (mainly mice), including drug dosing by various routes of administration (SC, IV, IP, oral gavage, IT); - Behavioral analysis of mouse models; - Ability to compile and analyze data using standard statistical methods. UMass Chan offers strong support and mentoring, a collaborative research environment, a competitive salary with benefits, and visa sponsorship available.  Interested applicants should submit the following materials via email to Susan Jacobs (susan.jacobs@umassmed.edu) and Robert Brown (robert.brown@umassmed.edu):  a cover letter describing current research activities and your interest in this position, a current CV (including publications), and contact information for three references, one of which should be your Ph.D. advisor.   

POSITION SUMMARY: Our research team conducts an array of studies related to addressing social disparities and perinatal and pediatric care. We work with directly with families with social disadvantage, including families with limited English proficiency, families of minoritized race/ethnicity, and those with low-income.  We do an array of clinical and health services research using qualitative and quantitative methods. We do observational and interventional studies. We are seeking a Clinical Research Coordinator II to join our growing, passionate research team and work under the direction of the Principal Investigator (PI) or designee. Tasks will involve a large array of procedures involving human subject research. This work includes coordination of regulatory activities and aspects of collection and management of data for research protocols related to treatment, ancillary services, and prevention practices. Our team is seeking a highly motivated individual with an interest in social determinants of health and addressing disparities in healthcare.

Post-Doctoral Researcher in Health Systems Science   We are seeking an exceptional postdoctoral fellow to join the Division of Health Systems at the University of Massachusetts Chan Medical School. Alzheimer's disease (AD) is the most common form of dementia characterized by progressive loss of cognitive function. Unfortunately, clinical interventions for AD have largely failed despite enormous efforts. The postdoc will work on the development of multimodal machine learning methods to integrate different datasets to investigate AD heterogeneity and risk. A wide range of data will be taken into consideration, including genetics data, neuroimages, and wearable devices. The postdoc will have the opportunity to work with an interdisciplinary team of investigators and receive diverse training opportunities in bioinformatics and machine learning.       

Post-doctoral positions are available for a Bill & Melinda Gates Foundation funded research project. The research focuses on determining the mechanism of recombinant adeno-associated virus (rAAV) vector DNA persistent gene expression.  The 3yr project will be supervised by Drs. Robert M. Kotin and Bo Tian at the University of Massachusetts Chan Medical School. Molecular biology laboratory experience is required, familiarity with cellular biology and biochemistry is preferred. TO APPLY: For further information, please send cover letter, current CV and the names and contact information of three references to: Robert Kotin PhD, Professor at Rober.Kotin@umassmed.edu  

POSITION SUMMARY:                                                   Under the direct supervision of the shift supervisor or designee, the Security and Safety Aide assists, monitors, and responds to security needs within the UMMS Chan Campus (Hospital and School). The Security and Safety Aide will focus on deterring crime and protecting the organization's property, assets, and people.

GENERAL SUMMARY OF POSITION:  Under the direction of the Principal Investigator or designee, the Research Nurse Coordinator II is responsible to carry out all delegated tasks related to complex protocols testing investigational drugs, devices, or research interventions. The Research Nurse Coordinator II is a primary resource for study protocol conduct acting as a liaison between the University of Massachusetts Chan Medical School, clinical partners (ex. University of Massachusetts Memorial Health Care (UMMHC)), the Principal Investigator, Institutional Review Board (IRB), and sponsors to ensure good clinical practice standards (GCP) throughout the life cycle of the study.    

The University of Massachusetts Medical School - Application Deadline: Open Until Filled Job Description Postdoctoral Associate in the Ceol lab. A postdoctoral position is available in the laboratory of Dr. Craig Ceol in the Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology at the University of Massachusetts Chan Medical School.  Our laboratory uses the zebrafish and mammalian cultured cells to study genes and biochemical mechanisms that regulate melanocyte regeneration and melanoma progression.  We utilize a range of genomic techniques to identify and study candidate genes and pathways.  We also complement these studies with unbiased genetic approaches designed to discover novel developmental and tumorigenic mechanisms.    Qualifications: - We are seeking a candidate who is motivated, enjoys creative thinking and brings enthusiasm to research.  - Candidates must have a recent Ph.D in the biological sciences. Tissue culture experience is preferred but not required.   To Apply:   Applicants should submit the following materials by email to craig.ceol@umassmed.edu:  a letter describing current research activities and your interest in this position, a CV (including publications), and contact information for three references, one of which should be your Ph.D. advisor.

POSITION SUMMARY:  Under the direction of the Principal Investigator or Designee, the Research Associate I performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION:   Reporting to the Senior Manager of Construction, the Facilities Construction Manager is responsible for oversight of construction activities on multiple projects on the Medical School campus and off-site properties. Duties include participation in the design, planning, specifications, construction schedules, estimates, contract documents, inspections, and project closeout for complex renovations, deferred maintenance and new construction projects. Project types are primarily focused on medical education, biomedical science, clinical science and research laboratory facilities.

We are inviting applications for postdoctoral positions to pursue multiple research topics that encompass: gene therapy using AAV vectors, RNA therapy, gene editing, immunology, virology, and AAV vector development.   Applicants should have a PhD degree or an MD with post-graduate scientific training, and at least three years of research experience in relevant areas such as Molecular Biology, RNA biology, Biochemistry, animal modeling, Immunology, Gene Therapy, Cell Therapy, Bioengineering, Neuromuscular Biology, Cell Biology, and Virology.   Applicants with backgrounds in molecular cloning, mouse work, NHP work, gene editing, microscopy, human and mouse genetics, next-gen sequencing, bioinformatics, single-cell sequencing, or protein/structural biology are preferred.    Applicants must also have the ability to work independently and coordinate multiple projects, concurrently. Strong writing, verbal, and interpersonal skills are required.     Candidates should be highly organized, hard-working, and motivated to respond to changes within the rapidly evolving field of gene therapy. We offer excellent training opportunities and a competitive salary depending on experience and track record. If you have any of the above attributes and skill sets, and believe you are a good fit for our research program, please send a cover letter, your CV, and contact information of three references to Guangping Gao at Guangping.Gao@umassmed.edu

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or designee, the Research Associate III performs a variety of complex research experiments.    

POSITION SUMMARY:  Under the direction of the Principal Investigator or Designee, the Research Associate I performs a variety of complex research experiments.    

We are inviting applications for postdoctoral positions to pursue multiple research topics that encompass gene therapy using AAV vectors, RNA therapy, virology, and AAV vector development. Applicants should have a PhD degree or an MD in relevant areas such as Molecular Biology, RNA biology, Biochemistry, Gene Therapy, Cell Therapy, Bioengineering, Neuromuscular Biology, Cell Biology, and Virology. Applicants with backgrounds in molecular cloning, mouse work, NHP work, microscopy, human and mouse genetics, bioinformatics, single-cell sequencing, or protein/structural biology are preferred.  Applicants must also can work independently and coordinate multiple projects, concurrently. Strong writing, verbal, and interpersonal skills are required.   Candidates should be highly organized, hard-working, and motivated to respond to changes within the rapidly evolving field of gene therapy. We offer excellent training opportunities and a competitive salary depending on experience and track record. If you have any of the above attributes and skill sets, and believe you are a good fit for our research program. To apply:  Please submit a cover letter and CV by email to Jun Xie at Jun.Xie@umassmed.edu

Research focus and environment: Three postdoctoral scholar positions are immediately available in the Zhong lab in the Horae Gene Therapy Center (GTC) and RNA Therapeutics Institute (RTI) at the University of Massachusetts Chan Medical School. The GTC and RTI are highly dynamic and collaborative departments, which consist of investigators from several academic departments at UMass Med and thus provide an exceptional environment for candidates seeking inter-disciplinary trainings. The Zhong lab’s research mainly focuses on engineering RNA switches and utilizing these molecular tools to develop temporally and spatially regulated gene-addition or gene-editing therapy technologies (eLife.2016; Nature Chemical Biology.2017; Molecular Therapy.2018; Nature Biotechnology.2020; an editorial commentary published in the journal Science Translational Medicine highlighting our recent Nature Biotech paper https://stm.sciencemag.org/content/12/529/eaba9016.full). We are applying these technologies to develop next generation gene therapies, which are safer and more efficacious than traditional unregulated gene therapies, for some rare genetic diseases and chronic metabolic/endocrine disorders. For more information about the PI’s prior research, please visit https://scholar.google.com/citations?hl=en&user=iOamZpMAAAAJ. Qualifications: - PhD in cellular and molecular biology, cellular and molecular physiology, biochemistry or related biological/biomedical science. - Highly motivated to apply skills towards solving molecular/biological problems. - Excellent experimental and analytical skills, and careful research-record keeping. - Good written and verbal communication/presentation skills. - Prior research experience in the following areas, including metabolic/endocrine disease molecular physiology, RNA biology/biochemistry, and bioinformatics, is advantageous but not required. Career development: The Zhong lab strongly supports postdoctoral researchers for their future career, including academic and biotech/pharma opportunities. As an equal opportunity and affirmative action employer, the University of Massachusetts Chan Medical School recognizes the power of a diverse community and encourages applications from individuals with varied experiences, prospectives, and backgrounds.   To apply: Please submit a cover letter and CV listing three references by email to Guocai Zhong at Guocai.Zhong@umassmed.edu

GENERAL SUMMARY OF POSITION:  Under the supervision of the Principal Investigator or designee, the Research Laboratory Technician I, performs a variety of specimen preparatory techniques, dry lab data collection, and routine laboratory maintenance.   Shaoguang Li, MD, PhD, has been working on understanding the biology of leukemia stem cells (LSCs) with a goal of developing more effective therapeutic strategies for leukemias. Recently, he has expanded his research into a new area: artificial intelligence (AI) in medicine. Specifically, his lab has developed unique algorithms for medical research, including, for example, the diagnosis of human lymphoma with high accuracy by reading pathological slides (Li D, Bledsoe JR, Zeng Y, Liu W, Hu Y, Bi K, Liang A, Li S. A deep learning diagnostic platform for diffuse large B-cell lymphoma with high accuracy across multiple hospitals. Nature Communications. 11(1):6004, 2020). He plans to further use the AI models established in his lab for studying molecular mechanisms underlying leukemogenesis and improving diagnostic accuracy of leukemias and solid tumors.

The University of Massachusetts Chan Medical School - Application Deadline: Open Until Filled Job Description Postdoctoral Associate in Molecular Neurobiology A postdoctoral associate position is available in the Richter Lab for a highly motivated candidate with a PhD in molecular biology. neurobiology, or a related discipline. The Richter Lab is part of a vibrant research environment of the Program in Molecular Medicine at the University of Massachusetts Chan Medical School and is highly collaborative with other labs within and external to UMMS. Work in the lab focuses on understanding the molecular basis of learning and memory, particularly as it relates to neurodevelopmental disorders including Fragile X Syndrome and autism. The selected candidate will apply a combination of up-to-the-minute molecular techniques to assess mRNA translation and splicing regulation in mouse models of Fragile X Syndrome as well as in human iPSC-derived neurons. The lab performs several types of RNA-seq and ChIP-seq, ribosome profiling, RNA-protein interaction analysis, mouse behavior, neuronal cultures, etc. We are developing new methods to mitigate Fragile X Syndrome. This project provides an excellent opportunity to learn and further develop a variety of techniques. The selected candidate will work independently to design and execute experiments.  Results of this project will be presented at seminars and scientific meetings, which may involve travel. The post-doctoral fellow will also prepare and submit manuscripts.   Qualifications: Education, experience and skills required for consideration: - Ph. D. in molecular biology, neurobiology, or related disciplines - Strong work ethic, highly motivated to apply skills towards solving biological problems - Excellent analytical skills and independent judgement - Highly collegial and works well as a team member - Strong written and verbal communication skills; ability to communicate with precision and tact - Meticulous record keeping, proficiency with databases - Relevant references: Shah et al (2020) Cell Reports 30:4459; Shu et al (2020) PNAS 117:30400; Liu et al (2018) PNAS 115:E11397. Shah et al (2023) PNAS : 120 (27) e2302534120 To Apply:   Applicants should submit the following materials by email to Joel.Richter@umassmed.edu:  a letter describing current research activities and your interest in this position, a CV (including publications), and contact information for three references, one of which should be your Ph.D. advisor.

GENERAL SUMMARY OF POSITION:   Under the general direction of the Academic Director and Trainer, of the Standardized Patient Program will teach and evaluate medical students, residents and graduate nurses.

The newly established Moore lab is looking for highly motivated post-doctoral fellows to be founding members of our team. We study gene regulation and its role in human disease by interpreting large scale multi-omic datasets using machine learning approaches.  Ideal candidates will have extensive experience in multi-omic data processing and analysis (RNA-seq, ATAC-seq, ChIP-seq, etc.) and are interested in learning about the fundamental mechanisms governing gene regulation (regulating transcription, splicing, translation, etc.). Candidates from related fields, such as computer science or biomedical engineering, with machine learning experience are also highly encouraged to apply.  To Apply: Interested candidates should email a cover letter, CV, and 3 references to: Jill Moore at Jill.Moore@umassmed.edu

GENERAL SUMMARY OF POSITION:     Under the general direction of the Principal Investigator or designee, the Research Associate IV performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.    

GENERAL SUMMARY OF POSITION:     Under the general direction of the Principal Investigator or designee, the Research Associate IV performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.