GENERAL SUMMARY OF POSITION:  Under the direction of the mental health nurse manager, functions as a professional by utilizing the nursing process in caring for psychiatric patients. Is responsible for incorporating general and unit specific competencies into nursing practice.  Adheres to UMMC nursing standards in accordance with licensure of Registered Nurses by the Commonwealth of Massachusetts.     

GENERAL SUMMARY OF POSITION:  Under the supervision of the Principal Investigator or designee, the Research Laboratory Technician I, performs a variety of specimen preparatory techniques, dry lab data collection, and routine laboratory maintenance.    

GENERAL SUMMARY OF POSITION:     Under the general direction of the Principal Investigator or designee, the Research Associate IV performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.    

GENERAL SUMMARY OF POSITION: Under the supervision of the Veterinary Services Supervisor or designee, provides clinical and laboratory support in the research animal facilities including specimen collection, treatments, assisting with rodent breeding colony management, animal health rounds and some surgical assistance. This position is considered essential, and as such requires weekend, holiday, and off hours coverage as needed and/or on a rotating basis.    

Development of novel ZFP-based gene therapy approaches for monogenic disorders.   The Wolfe laboratory will be filling a postdoctoral position to develop new gene therapy reagents for the treatment of monogenic disorders in collaboration with other laboratories within UMMS. These efforts will focus on the creation of novel Cys2His2 zinc finger protein-based therapeutics for delivery to affected cell types.  This project will focus on:   1) The development of Cys2His2 zinc finger proteins (ZFPs) with novel DNA binding specificity to target specific (therapeutic) genomic loci.   2) The application of these ZFPs in cell culture and in vivo models of disease to abrogate disease-associated phenotypes.     These studies will expose the successful candidate to cutting-edge ZFP design and selection approaches, as well as in vitro and in vivo delivery approachs.  The successful candidate will also learn cutting edge deep-sequencing approaches to monitor the genome-wide binding locations and impact of the ZFPs on the genome and transcriptome. The successful candidate will have the opportunity to participate in meetings/conferences associated with gene therapy, which will broaden their exposure to cutting edge research within the field. In addition, the successful candidate will learn to utilize CRISPR-Cas9 and CRISPR-Cas12a nuclease technologies that are being developed in the Wolfe laboratory. Candidates should have a Ph.D. in biology, biochemistry, chemistry or a related biomedical science. In addition, the potential candidate must have strong oral and written communication skills and be eager to present research results at national meetings. Prior experience with Cys2His2 zinc finger proteins, cell culture, and deep-sequencing technologies is advantageous, but not required.   Applicants should send a letter (via email) describing their current research activities and their interest in this position, a CV (including publications) and contact information for three references, including your Ph.D. advisor.   Address letters to Scot Wolfe (scot.wolfe@umassmed.edu). University of Massachusetts Chan Medical School Department of Molecular, Cell and Cancer Biology 364 Plantation Street, LRB Room 619 Worcester, MA 01605   Further details about the Wolfe laboratory and the positions that are available can be found at https://www.umassmed.edu/Wolfe-Lab/ https://profiles.umassmed.edu/display/133161   UMass Medical School is committed to being an equal opportunity and affirmative action employer and recognizes the power of a diverse community. We encourage applications from protected veterans, individuals with disabilities and those with varied experiences, perspectives and backgrounds to consider UMass Medical School as their employer of choice.

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or designee, the Research Associate III performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION:  Under the supervision of the Principal Investigator or designee, the Research Laboratory Technician I, performs a variety of specimen preparatory techniques, dry lab data collection, and routine laboratory maintenance.    

POSITION SUMMARY: Under the direction of the Principal Investigator (PI) or designee, the Clinical Research Coordinator I is responsible for independently performing delegated tasks and procedures involving human subject research. This work includes coordination of regulatory activities and aspects of collection and management of data for research protocols related to treatment, ancillary services, and prevention practices.    

We are a young, dynamic group looking for highly motivated post-doctoral fellows with research interests in host genetics and viral interactions in Alzheimer’s Disease (AD). We develop inter-disciplinary methods including experimental techniques and technology development around hiPSCs from AD patients, as well as computational and statistical genetics/genomics methods. Ideal candidates have strong backgrounds in human induced pluripotent stem cells (hiPSCs) and neuronal differentiation, and experience with flow cytometry, FACS sorting and CRISPR/Cas9 editing. Candidates with strong backgrounds in quantitative human genetics and genomics, bioinformatics or computational biology, and who are interested in learning experimental techniques and technologies to complement their quantitative backgrounds, are also highly encouraged to apply. To Apply: Interested candidates should email a cover letter, CV, and 3 references to: Elaine Lim at Elaine.Lim@umassmed.edu

Postdoctoral Research Associate, Computational Biology The Karlsson Lab in the Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School seeks a computational postdoctoral associate to work with us on a new NSF-funded project to discover the genomic basis of cellular robustness in organisms with flexible homeostasis. Our project is investigating epigenetic responses in cells of species that tolerate reduced blood oxygen during deep diving, elevated blood glucose during frugivory, and circadian and seasonal shifts in body temperature.  The ideal candidate will be experienced in computational biology, statistical inference, R, and command-line coding. The post doc will collaborate with scientists at UMass Medical School, Broad Institute, University of Minnesota, and University of Nevada to develop integrated computational analysis of genomic, epigenomic, transcriptomic and cell-morphology data from cells cultured under conditions that model variation in an organism's internal milieu. The post doc will also have the opportunity to contribute to outreach programs that engage middle school students to develop their skills in coding and experimental design. TO APPLY: For further information, please send cover letter, current CV and the names and contact information of three references to: Elinor Karlsson, Associate Professor at Elinor.Karlsson@umassmed.edu

The Flavahan lab has postdoctoral training positions available, focused on cancer epigenetics and chromatin biology.  We use cutting-edge techniques to investigate the cancer epigenome.  First, we seek to uncover how cryptic tumor drivers, such as mutations in metabolic enzymes or histone subunits, signal through the epigenome to activate oncogenic pathways.  Second, we are examining how the three-dimensional structure of the genome directs cancer cell responses and tumor progression.  Postdoctoral positions are available for these and related projects.  Experience in brain tumor or epigenetic research is preferred but not required.   For further information, please send a cover letter briefly detailing your research interests, current CV, and the names and contact information of three references to: William Flavahan PhD, Assistant Professor at William.Flavahan@umassmed.edu