GENERAL SUMMARY OF POSITION:     We currently have an opening for a Research Associate to join the laboratory of Dr. Michelle Kelliher at the University of Massachusetts Chan Medical Center. The Kelliher lab studies how leukemia develops using genetically engineered mouse models and patient derived xenografts. We are focused on understanding the molecular and cellular basis of chemoresistance and relapse in an effort to develop novel therapeutic approaches. Our lab uses innovative mouse modeling approaches and single cell sequencing and chromatin accessibility methods to identify features of leukemic stem or initiating cells thought to mediate relapse. This position offers opportunities for career development, including possibly designing and executing independent experiments which could lead to publication.

The University of Massachusetts Medical School - Application Deadline: Open Until Filled Job Description Postdoctoral Associate in the Ceol lab. A postdoctoral position is available in the laboratory of Dr. Craig Ceol in the Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology at the University of Massachusetts Chan Medical School.  Our laboratory uses the zebrafish and mammalian cultured cells to study genes and biochemical mechanisms that regulate melanocyte regeneration and melanoma progression.  We utilize a range of genomic techniques to identify and study candidate genes and pathways.  We also complement these studies with unbiased genetic approaches designed to discover novel developmental and tumorigenic mechanisms.    Qualifications: - We are seeking a candidate who is motivated, enjoys creative thinking and brings enthusiasm to research.  - Candidates must have a recent Ph.D in the biological sciences. Tissue culture experience is preferred but not required.   To Apply:   Applicants should submit the following materials by email to craig.ceol@umassmed.edu:  a letter describing current research activities and your interest in this position, a CV (including publications), and contact information for three references, one of which should be your Ph.D. advisor.

POSITION SUMMARY:  Under the direction of the Principal Investigator or Designee, the Research Associate I performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION: Under the general direction of the Associate Director–Facilities Engineering and Construction or designee, the Construction Project Manager is responsible for the supervision, administration and resident engineering of construction projects at University of Massachusetts Chan Medical School and Satellite Campuses, as performed by outside contractors.    

We are inviting applications for postdoctoral positions to pursue multiple research topics that encompass: gene therapy using AAV vectors, RNA therapy, gene editing, immunology, virology, and AAV vector development.   Applicants should have a PhD degree or an MD with post-graduate scientific training, and at least three years of research experience in relevant areas such as Molecular Biology, RNA biology, Biochemistry, animal modeling, Immunology, Gene Therapy, Cell Therapy, Bioengineering, Neuromuscular Biology, Cell Biology, and Virology.   Applicants with backgrounds in molecular cloning, mouse work, NHP work, gene editing, microscopy, human and mouse genetics, next-gen sequencing, bioinformatics, single-cell sequencing, or protein/structural biology are preferred.    Applicants must also have the ability to work independently and coordinate multiple projects, concurrently. Strong writing, verbal, and interpersonal skills are required.     Candidates should be highly organized, hard-working, and motivated to respond to changes within the rapidly evolving field of gene therapy. We offer excellent training opportunities and a competitive salary depending on experience and track record. If you have any of the above attributes and skill sets, and believe you are a good fit for our research program, please send a cover letter, your CV, and contact information of three references to Guangping Gao at Guangping.Gao@umassmed.edu

GENERAL SUMMARY OF POSITION: Under the direction of the Principal Investigator or designee, the Research Coordinator I is responsible for carrying out multiple complex research protocols.    

POSITION SUMMARY:  Lab information https://www.umassmed.edu/Wolfe-Lab/   Additional Information: The focus of the Wolfe Laboratory is the development of genome editing (CRISPR/Cas systems) and gene regulation (zinc finger proteins) tools for the development of new classes of therapeutics. The successful candidate would be a part of an interdisciplinary team of laboratory scientists, clinicians, and computational biologists that are working on therapeutics for a variety of hematopoietic and neuromuscular disorders. We are looking for a candidate that would be a key player in purifying and characterizing novel genome editing proteins that would be used to develop therapies for these disorders – with these reagents potentially being used in clinical trials.    Experience Required: None   Experience Desired (not required): - Protein purification (AKTA-based) - Protein Characterization and QC assays - Basic molecular biology techniques (PCR, Restriction Enzyme mediated cloning, Gel electrophoresis, Qiagen DNA miniprep).    - Mammalian Cell culture experience. - Genome editing experience Major Responsibilities (in addition to the standard set): - Participate in the purification and characterization of various genome editing proteins. - Participate in the characterization of the activity quality of proteins that are produced for using in vivo and ex vivo - Organize ordering and stocking of supplies and reagents for protein production facility.    

GENERAL SUMMARY: Under the general supervision of the Director or designee, the Building Automation Technician I will be responsible for the safe, reliable and economical operation of the building automation systems. This position is responsible for executing technical service of all building control   

GENERAL SUMMARY OF POSITION:     Under the general direction of the Senior Director or designee, the Senior Architectural Project Manager is responsible for the management and general supervision of the Architectural Project Management Group and the architectural design of infrastructure and capital projects at the University of Massachusetts Chan Medical School Campus and/or Off-site Facilities.    

GENERAL SUMMARY OF POSITION:  Under the general direction of the Director of Facilities Maintenance or designee, the Assistant Director of Facilities Maintenance is responsible for the timely and cost-efficient management and repair of facilities, buildings and grounds. This position supervises maintenance staff and/or outside contractors in the performance of these tasks.

GENERAL SUMMARY OF POSITION:   Under the direct supervision of the Supervisor or designee, the Janitor performs general janitorial and custodial work in connection with cleaning and maintenance of a building, or a group of buildings.    

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

Post-Doctoral Fellowship in Maternal and Child Mental Health Jumpstart your professional career in maternal and child mental health and integrated behavioral health care with national innovators at the Lifeline for Families Center at the UMass Chan MedicalSchool. This 2-year, research-focused post-doctoral fellowship provides training on integrating mental healthcare into maternal and child health care settings that have not traditionally provided mental health care. Fellows will work on projects that aim to build the capacity of maternal and child health care providers to address mental health and substance use disorders among pregnant and postpartum (perinatal) individuals and their children. Studies range from outpatient Ob/Gyn and pediatric settings to community settings and include developing, implementing and evaluating innovative approaches to increase access to care through capacity building.  Fellows will work on existing federally funded clinical and implementation studies and be involved with grant submissions. Fellows also have the opportunity to work on population-based statewide programs focused on building the capacity of the medical community to address perinatal mental health and substance use disorders in Massachusetts (Massachusetts Child Psychiatry Access Program (MCPAP) for Moms (www.mcpapformoms.org)) and other states through our National Network of Perinatal Psychiatry Access Programs.   This fellowship will be tailored to the career goals of the individual. Fellows can opt to work on a statewide system to increase access to evidence-based trauma services and medical and community supports for children impacted by trauma and adversity and, if interested, can develop training skills in trauma-informed care and trauma-responsive practices to be able to train other providers in various settings.     Current active research includes NIH, CDC, PCORI, SAMHSA, foundation, and state funded projects. Our faculty are pioneers in the fields of psychiatry, psychology, obstetrics and gynecology (Ob/Gyn), and pediatrics, leading paradigm-shifting work focused on addressing parental and child mental health. Together, we have collective experience, expertise in parental and child mental health, and deep relationships with community partners, including medical societies and policymakers. In collaboration with these community partners, we support fellows in developing, implementing, and testing interventions that increase access to, and engagement in, evidence-based mental health care for families.  Our prior and ongoing projects focus on: - Building the capacity of nontraditional settings and developing practical approaches to address mental health as part of perinatal, infant, and child health care, no matter what door the family enters. - Creating feasible and scalable care delivery models, trainings, and tools for families to be supported by the professionals they present to, regardless of that professional’s specific discipline. - Doing work that is scalable, replicable, evidence based, and already implemented nationwide. - Creating innovative solutions are driven by our research, the voices of community partners, and others’ research. Clinical activities across a range of illnesses and settings enhance the fellow’s ability to integrate physiological and psychological information into health psychology treatment plans for pregnant and postpartum individuals and children, how to expand and augment integrated care. Supervisors and mentors are committed to evidence-based practice and provide supervision across a variety of empirically supported treatments, including Cognitive-Behavioral Therapy, Health Psychology, Motivational Interviewing, evidence-based trauma therapies (e.g., Trauma-Focused Cognitive-Behavioral Therapy), and mindfulness-oriented therapies. Fellows will primarily work with Nancy Byatt, DO, MS, MBA, DFAPA, FACLP, the Executive Director of Lifeline for Families. The fellow will also work with other Lifeline for Families faculty including Tiffany Moore Simas, MD, MPH, MEd, FACOG, Jessica Griffin, PsyD, Heather Forkey, MD,  Ed Tronick, PhD, Dorothy Richardson, PhD, and Martha Zimmermann, PhD. The fellow is encouraged and supported to obtain their license after their first year of training.   About UMass Medical School: UMass Chan Medical School and its clinical partner, UMass Memorial Health, is a thriving academic health care system located in Worcester MA, about an hour’s drive west of Boston. The environment provides a highly supportive home for fellows, with opportunities to collaborate with leading researchers and engage in meaningful clinical work.   How to Apply: A PhD or PsyD in clinical psychology or related field and completion of an APA-accredited internship with relevant experience is required. Applications will be accepted on an ongoing basis until the position is filled. Send a detailed letter of interest that specifies the fellowship of interest and summarizes relevant experiences and career goals, curriculum vitae, and three letters of reference to robyn.leonard@umassmed.edu or by mail to:   c/o Robyn Leonard:   Nancy Byatt, DO, MS, MBA, DFAPA, FACLP Professor with Tenure, Departments of Psychiatry, Obstetrics and Gynecology, and Population and Quantitative Health Sciences Executive Director, Lifeline for Families Center and Lifeline for Moms Program at the UMass Chan Medical School Medical Director of Research and Evaluation, Massachusetts Child Psychiatry Access Program (MCPAP) for Moms   As an equal opportunity and affirmative action employer, UMMS recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives, and backgrounds.

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or designee, the Research Associate III performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION: Under the direction of the Principle Investigator or designee, the Research Data Specialist collaborates in the implementation of the data management procedures and organizational activities. This position coordinates the information retrieved from databases and performs in-depth analyses in order to track programs and projects within the group.

GENERAL SUMMARY OF POSITION:   We currently have an opening for a Research Associate to join the laboratory of Dr. Michelle Kelliher at the University of Massachusetts Chan Medical Center. The Kelliher lab studies how leukemia develops using genetically engineered mouse models and patient derived xenografts. We are focused on understanding the molecular and cellular basis of chemoresistance and relapse in an effort to develop novel therapeutic approaches. Our lab uses innovative mouse modeling approaches and single cell sequencing and chromatin accessibility methods to identify features of leukemic stem or initiating cells thought to mediate relapse. This position offers opportunities for career development, including possibly designing and executing independent experiments which could lead to publication. Preferred Qualifications: - Mouse experience is highly desired but not required - Self-motivated, detail-oriented, and able to perform complex tasks effectively and independently with general instruction - Ability to work in a team-focused environment - Excellent communication and computer skills  

POSITION SUMMARY:  We currently have an opening for a Research Associate I to join the laboratory of Dr. Michelle Kelliher at the University of Massachusetts Chan Medical Center. The Kelliher lab studies how leukemia develops using genetically engineered mouse models and patient derived xenografts. We are focused on understanding the molecular and cellular basis of chemoresistance and relapse in an effort to develop novel therapeutic approaches. Our lab uses innovative mouse modeling approaches and single cell sequencing and chromatin accessibility methods to identify features of leukemic stem or initiating cells thought to mediate relapse. This position offers opportunities for career development, including possibly designing and executing independent experiments which could lead to publication.    

GENERAL SUMMARY OF POSITION: Under the general supervision of the Program Director or designee, participates as a member of the mental health treatment team in an intensive treatment program. Assist with the delivery of direct care, including provision for safety and milieu activities. Take an active role in re-acclimating individuals to the larger community. Provide trauma informed care and promote a person-centered, skills-based collaborative philosophy. The milieu counselor participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.

JOB DESCRIPTION: The Department of Biochemistry and Molecular Pharmacology invites applications or a postdoctoral position in the laboratory of Dr. William Kobertz. This position is for an applicant who will use cellular imaging and electrophysiological techniques to fluorescently visualize extracellular K+ over the varied cardiomyocyte landscape. Applicants are expected to be able to design and conduct experiments independently. Visit the Kobertz lab: https://www.umassmed.edu/kobertzlab/ JOB REQUIREMENTS: Full-time postdoctoral position requiring a Ph. D. in neuroscience, biophysics, physiology, or related field. AREAS OF EXPERTISE: Whole cell patch clamp electrophysiology with mammalian cells is required. Patch-clamp fluorometry and isolation and culturing of primary mammalian cardiomyocytes, neurons, and astrocytes is desired, but not required. TO APPLY: Applicant should send or email their CV, including the names of three references to: william.kobertz@umassmed.edu