The Horae Gene Therapy Center of the University of Massachusetts Chan Medical School invites applications for a postdoctoral researcher position to develop AAV-based gene therapy technologies using genome editing and RNA-based methods.   Applicants should have a PhD degree in relevant areas such as molecular biology, RNA biology, biochemistry, and virology. Applicants of diverse research background are encouraged to apply, such as neuroscience, mouse genetics, bioengineering, and cell biology. Applicants highly skilled in molecular cloning, mouse work, deep sequencing and data analysis (Illumina, PacBio, Nanopore), are preferred. Applicants must also have the ability to work independently, coordinate multiple projects and activities concurrently. Strong writing, verbal, and interpersonal skills are required.  Candidates should be highly organized, hard-working and motivated to respond to the changes within the rapidly evolving field of gene therapy. We offer excellent training opportunities and a competitive salary depending on experience and track records.For further information, please send cover letter, CV and contact information of three references to:     Dan Wang, Ph.D. Assistant Professor Horae Gene Therapy Center & RNA Therapeutics Institute University of Massachusetts Chan Medical School AS6-2061, 368 Plantation Street Worcester, MA 01605   Phone: (774)-455-4574 E-mail:  dan.wang@umassmed.edu Lab website: https://www.umassmed.edu/wanglab/   UNIVERSITY OF MASSACHUSETTS CHAN MEDICAL SCHOOL The University of Massachusetts Chan Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research.  As a research institution, UMass Chan attracts nearly $300 million annually in funding from government agencies, private groups, and philanthropic organizations.  Faculty members are nationally recognized authorities in areas ranging from cancer to diabetes to genetics and are regularly honored for their work.   As an equal opportunity and affirmative action employer, UMass Chan recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives and backgrounds

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or designee, the Research Associate III performs a variety of complex research experiments.    

POSITION SUMMARY:  Under the direction of the Principal Investigator or Designee, the Research Associate I performs a variety of complex research experiments.   The Watts Lab is making a new generation of oligonucleotide tools and therapeutics by working at the interface of chemistry and biology, including gene silencing, gene activation, and genome editing.    

The Tai and Gao labsof the Horae Gene Therapy Center at the UMass Chan Medical School are inviting applications for postdoctoral positions to pursue multiple research topics that encompass: gene therapy using AAV vectors, RNA therapy, gene editing, immunology, virology, and AAV vector development.   Applicants should have a PhD degree or an MD with post-graduate scientific training, and at least three years of research experience in relevant areas such as Molecular Biology, RNA biology, Biochemistry, animal modeling, Immunology, Gene Therapy, Cell Therapy, Bioengineering, Neuromuscular Biology, Cell Biology, and Virology.   Applicants with backgrounds in molecular biology, mouse work, NHP work, gene editing, microscopy, human and mouse genetics, next-gen sequencing, bioinformatics, single-cell sequencing, or protein/structural biology are preferred.    Applicants must also have the ability to work independently and coordinate multiple projects, concurrently. Strong writing, verbal, and interpersonal skills are required.     Candidates should be highly organized, hard-working, and motivated to respond to changes within the rapidly evolving field of gene therapy. We offer excellent training opportunities and a competitive salary depending on experience and track record.If you have any of the above attributes and skill sets, and believe you are a good fit for our research program, please send a cover letter, your CV, and contact information of three references to:   Phillip Tai, Ph.D. Assistant Professor, Horae Gene Therapy Center and Vector Core E-mail: phillip.tai2@umassmed.edu   The UMass Chan Medical School, one of the fastest growing academic health centers in the country, has built a reputation as a world-class research institution, consistently producing noteworthy advances in clinical and basic research.  As a research institution, UMMS attracts nearly $300 million annually in funding from government agencies, private groups, and philanthropic organizations.  Faculty members are nationally recognized authorities in areas ranging from cancer to diabetes to genetics and are regularly honored for their work.   As an equal opportunity and affirmative action employer, UMass Chan recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives and backgrounds

GENERAL SUMMARY OF POSITION: Under the direction of a member of the faculty, the Bioinformatician is responsible for the design, development, evaluation and iterative modification of a technical infrastructure to expedite the quantitative evaluation of data resulting from studies that are laboratory based.  The position will entail the establishment and maintenance of applicable in-house bioinformatics resources and interaction with individual lab members on customized research projects, as well independent projects that are the solely computational.   

GENERAL SUMMARY OF POSITION:     Under the general direction of the Principal Investigator or designee, the Research Associate IV performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.    

GENERAL SUMMARY OF POSITION:   Under the direction of the Principal Investigator or designee, the Research Associate III performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION:  Under the direction of the mental health nurse manager, functions as a professional by utilizing the nursing process in caring for psychiatric patients. Is responsible for incorporating general and unit specific competencies into nursing practice.  Adheres to UMMC nursing standards in accordance with licensure of Registered Nurses by the Commonwealth of Massachusetts.     

GENERAL SUMMARY OF POSITION:  Under the general direction of the Clinical Director or designee, the Social Worker I participates as an interdisciplinary member of the treatment team providing trauma-informed care and promoting a person-centered, skills-based collaborative philosophy in conjunction with the individual, and/or the individual’s family, state, and community agencies/programs. The Social Worker I participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.  

POSITION SUMMARY:  The Recovery Support Specialist provides peer recovery support services to patients with substance use disorder (SUD) and will assist patients in achieving sustained recovery.  Facilitates patient access to recovery­ oriented substance use disorder treatment, resources, and community recovery groups. Bridges the segregated treatment system into a more holistic care model through providing support across multiple systems of care.  Maintain ongoing patient support regardless of client relapse and will serve as a motivator, ally, role model, problem-solver, and advocate for patients with substance use disorders.  Possesses thorough understanding of community culture to address the barriers to successful recovery, better tailor health messages, and provide links to community resources and treatment options. 

GENERAL SUMMARY OF POSITION:  Under the general supervision of the Principal Investigator or designee, the Nurse Practitioneras a member of research team is responsible for independently carrying out multiple complex research protocol designed to test the efficacy of a behavioral intervention; select and monitor test populations; provide expert consultation to clinical research staff; collect and help analyze data; report findings to principal investigator, and IRB when necessary. 

We are seeking an outstanding individual for a fully funded postdoctoral position in the laboratories of Dale Greiner, Ph.D. and Michael Brehm, Ph.D. Our laboratories are developing a number of cutting-edge humanized mouse models to study type 1 diabetes. Our research interests include; 1) effector functions of human autoreactive T cells, 2) interactions between autoreactive T cells and human pancreatic beta cells and 3) identifying immune therapeutics that suppress the destruction of human beta cells by autoreactive T cells. To address these interests, we use a number of approaches including immunological, cellular, molecular and genomic. In addition to learning multidisciplinary approaches to study human type 1 diabetes, the candidate will have opportunities for career development in both academic and private sectors. To Apply: Interested candidates should email a cover letter, CV, and 3 references to: Michael Brehm at Michael.Brehm@umassmed.edu

GENERAL SUMMARY OF POSITION:  Under the supervision of the Principal Investigator or designee, the Research Laboratory Technician I, performs a variety of specimen preparatory techniques, dry lab data collection, and routine laboratory maintenance.    

GENERAL SUMMARY OF POSITION:    Under the direct supervision of a Principal Investigator or designee, the Research Lab Tech II performs and interprets routine and highly complex experiments.   This position will support the Tissue Culture & Enzyme Freezer Core Facility. Duties will include assisting with receiving and packaging customer orders, data entry for invoicing, and significant amounts of filing and collating. The Research Lab Tech II is expected to present a courteous, professional manner when dealing with customers.  

  GENERAL SUMMARY OF POSITION: Under the direction of a member of the faculty, the Bioinformatician is responsible for the design, development, evaluation and iterative modification of a technical infrastructure to expedite the quantitative evaluation of data resulting from studies that are laboratory based.  The position will entail the establishment and maintenance of applicable in-house bioinformatics resources and interaction with individual lab members on customized research projects, as well independent projects that are solely computational.  The Maehr lab is seeking a highly motivated individual to work with a team of researchers to broaden their understanding of the underlying cause of autoimmune diabetes, and how novel stem cell therapy approaches can be optimized for innovative treatment strategies and immune modulations.  

GENERAL SUMMARY OF POSITION:     Under the general direction of the Principal Investigator or designee, the Research Associate IV performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Gene Therapy Center.    

POSITION SUMMARY:  Under the direction of the Principal Investigator or Designee, the Research Associate I performs a variety of complex research experiments.    

GENERAL SUMMARY OF POSITION:  Under the direction of the mental health nurse manager, functions as a professional by utilizing the nursing process in caring for psychiatric patients. Is responsible for incorporating general and unit specific competencies into nursing practice.  Adheres to UMMC nursing standards in accordance with licensure of Registered Nurses by the Commonwealth of Massachusetts.     

GENERAL SUMMARY OF POSITION:  Under the general direction of the Clinical Director or designee, the Social Worker I participates as an interdisciplinary member of the treatment team providing trauma-informed care and promoting a person-centered, skills-based collaborative philosophy in conjunction with the individual, and/or the individual’s family, state, and community agencies/programs. The Social Worker I participates in a process of continuous learning and demonstrates openness to evolving philosophies of practice, including restraint and seclusion prevention.