POSITION SUMMARY: 

Under the direction of a member of the faculty, the Bioinformatician is responsible for the design, development, evaluation and iterative modification of a technical infrastructure to expedite the quantitative evaluation of data resulting from studies that are laboratory based.  The position will entail the establishment and maintenance of applicable in-house bioinformatics resources and interaction with individual lab members on customized research projects, as well independent projects that are the solely computational.  

This is an open-rank posting (there are 4 levels of Bioinformatician) - candidates will be hired into the level commensurate with their experience.

ESSENTIAL FUNCTIONS:

Bioinformatician I:

• Establish general bioinformatics resources for day-to-day use by members of the laboratory
• In collaboration with a faculty member, generate customized programming solutions to improve user interaction with available bioinformatics resources
• Assist in the implementation of programs for microarray analysis, high-throughput sequencing data analysis, cis regulatory motif identification, and multi-genome protein motif searches
• Local establishment and customization of model organism genomic databases and tools for batch sequence analysis utilizing these resources
• Interpret and present study results in support of laboratory members
• Provide tabular and written summaries of approaches and analyses in a form suitable for inclusion in manuscripts or grant applications, as well as media for presentation at scientific meetings
• Develop and implement custom bioinformatics programming solutions in collaboration with lab as necessary
• Coordinate and collaborate with other research computing expertise at the Medical School as necessary
• Participate in conference calls and data management meetings as needed
• Perform other duties as required.

Bioinformatician II:

Duties noted above plus:

• Implement and adapt programs for microarray analysis, high-throughput sequencing data analysis, cis regulatory motif identification, and multi-genome protein motif searches.
• Independently develop, implement and maintain custom designed computational solutions relevant for ongoing lab-based projects.
• Independently develop, implement and maintain computational methods for meta-analysis of data generated in the lab as well as publicly available data.
• Independently execute a scientific computational project (e.g. a project that can result in a first author publication)

Bioinformatician III:

Duties noted above plus:

• Design and implement reusable bioinformatics analysis pipelines for processing next-generation sequencing, microarray, genomics, proteomics and chemogenomics data.
• Integrate computational methods/pipelines with high performance computing clusters.
• Collaborate closely with PIs and their lab members on research projects including defining the scope of the collaboration, researching on the scientific topics, and implementing the appropriate bioinformatics solutions that meet timelines.
• Participate in the oral presentation of all project findings and abstracts including participation in periodic project status meetings and presentation of final project deliverables.
• Develop rapid prototypes and custom scripts for one-off type of analysis requests.
• Develop novel algorithms and integrated data visualization applications when existing software packages are not available or adequate.
• Properly document the procedures used in computational analysis and provide summary report of results suitable for inclusion in manuscript and grant applications.
• Local establishment and customization of genomic, proteomics databases and provide batch analysis utilities that make use of these resources.
• Develop custom databases and web portals for managing raw and processed experimental data.
• Provide bioinformatics training and workshops for analysis pipelines and in-house developed software applications.
• Coordinate and collaborate with other bioinformaticians, biostatisticians, information technology professionals, and interdepartmental project teams.

Sr Bioinformatician:

Duties noted above plus:

• Lead the design and implementation of reusable bioinformatics analysis pipelines for processing next-generation sequencing, microarray, genomics, proteomics and chemogenomics data. Ensure pipelines meet end-user needs and project timelines
• Independently initiate and manage research collaborations. Work closely with PIs and their lab members on research projects including defining the scope of the collaboration, researching on the scientific topics, and implementing the appropriate bioinformatics solutions
• Closely follow the latest development in high-through technologies, pioneer in bioinformatics analysis on novel datasets and facilitate sharing of knowledge and best practices
• Independently develop novel algorithms and bioinformatics applications when existing software packages are not available or adequate
• Prepare scientific manuscripts and abstracts including primary authorship of bioinformatics research papers
• Organize bioinformatics training and workshops for analysis pipelines and in-house developed software applications
• Liaison with Information System department to ensure high performance computing needs for research are properly addressed
• Mentor rotation and summer internship students and junior members in the group

REQUIRED QUALIFICATIONS:

Bioinformatician I:

• BS in computer science or a related discipline  
• 0-1 year of related experience
• Strong background in statistical methodology, software languages and computer systems (Perl, C++, R, MySQL, etc.)
• Experience in writing basic search algorithms and the ability to generate new algorithms and programs for custom data manipulation and analysis
• Excellent communication skills, both oral and written, and interpersonal skills necessary to interact with a wide range of individuals

Bioinformatician II:

• Requirements noted for Bioinformatician I plus:
• 1-3 years of related experience
• Co-authorships on peer-reviewed publications are strongly suggested but not required

Bioinformatician III:

• Requirements noted for Bioinformatician I plus:
• Master's degree in Computer Science, a related computational discipline, or equivalent experience
• 1-3 years of bioinformatics-related research experience
• Proven research record such as co-authorship on peer-reviewed publications required
• Strong background in programming. Fluent in one programming language (Java or C/C++) and one scripting language (shell, Perl or Python)
• Knowledge in biostatistics packages (R or Matlab) and SQL queries are strongly suggested
• Strong communication skills, both the oral and written necessary to interact with a wide range of individuals

Sr Bioinformatician:

• Requirements noted for Bioinformatician I plus:
• Master's degree in Bioinformatics, Computer Science, or related computational discipline
• 3-5 years bioinformatics-related research experience
• Knowledge in biostatistics packages (R or Matlab) and SQL queries preferred
• Highly self-motivated and demonstrated ability to manage internal and external collaborations

The research goal of the Schreiber Lab is to understand the regulatory role of each nucleotide in the human genome and how this changes across every cell in the body. In lieu of massive experimental efforts, we use statistical and deep learning methods to comprehensively address this question.