Function: The lab studies the expression and function of genes involved in Programmed Cell Death (Apoptosis), survival signaling and compensatory proliferation using Drosophila as a model system. Individual must be capable of conducting independent research projects in this scientific area under the supervision of the faculty member.
Scope: Responsible for efficient planning and execution of research projects in consultation with the faculty member. Requires working with laboratory fruit fly, Drosophila melanogaster, which includes maintaining stocks, establishing stocks, setting up and scoring genetic crosses and genetic screens, dissecting and immunostaining tissues, and documentation of scientific data as necessary. Requires working with nucleic acids (molecular biology) and proteins. Must be able to develop and/or modify new techniques.
Pérez E, Lindblad JL and Bergmann A (2017). Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila. eLife 6: e26747.
Amcheslavsky A, Wang S, Fogarty CE, Lindblad, JL, Fan Y and Bergmann A (2018). Plasmamembrane-localization of apoptotic caspases for non-apoptotic functions. Developmental Cell 45: 450-464.
Diwanji N and Bergmann A (2019). Two sides of the same coin – compensatory proliferation in regeneration and cancer. In: Drosophila model in cancer. Ed.: Wu-Min Deng. Adv Exp Med Biol;1167:65-85. doi: 10.1007/978-3-030-23629-8_4.
Diwanji N and Bergmann A (2020). Basement Membrane damage by ROS- and JNK-mediated Mmp2 activation drives macrophage recruitment to overgrown tissue. Nature Communications. 11:3631. doi: 10.1038/s41467-020-17399-8.