University of Massachusetts Medical School

  • Post Doctoral Associate

    Minimum Salary US-MA-Worcester
    Job Location 1 month ago(1 month ago)
    Requisition Number
    2018-31319
    # of Openings
    1
    Posted Date
    Day
    Shift
    Exempt
    Exempt/Non-Exempt Status
    Non Union Position-W63-Residents/Post Docs
  • Overview

     

     

    Responsibilities

    Postdoctoral Fellow – Systemic Autoimmunity

    Department of Medicine/Rheumatology, University of Massachusetts Medical School

    Responsibilities

    Design and carry out experiments to explore one or more of the following topics:  molecular mechanisms by which TLR9 negatively regulates T cell activation in murine models of systemic autoimmunity; regulation and gene expression profiles of skin-associated immune cells from cutaneous lupus patients and murine model of cutaneous lupus (Mande P, et al., 2018, JCI) by both high resolution flow cytometry and single cell RNAseq; immune defects of mice that express a gain-of-function (SAVI) mutation.  These projects include collaborations with Drs. John Harris and Kate Fitzgerald.

     

    Expectations also include preparation of oral presentations for program/department research in progress meetings, submission of abstracts for poster and oral presentations at national/international meetings, and oversight of technician and/or student working on related projects.

    Qualifications

    REQUIRED QUALIFICATIONS:

     

    • Highly motivated investigator with a PhD in Immunology, Cell Biology, Molecular Biology or related discipline.
    • Working knowledge of cellular immunology, B and T cell development, and innate immune pathways.
    • Hands-on laboratory experience in relevant methodologies, trouble-shooting technical problems, and data analysis skills.
    • Experience in the following techniques preferred:  handling/injecting/genotyping mice, preparation of lymphoid and dermal/epidermal tissues for histology, isolation and cell culture of lymphocyte populations, multicolor flow cytometry, DNA/RNA purification and quantification, qPCR, enzyme-based immunoassays, and immunofluorescent/confocal microscopy, database comparisons.
    • Outstanding organizational and time management skills, as well as the ability to work both independently and as part of a team in a fast-paced environment.

     

    Additional Information

    Find out more about the UMMS research community at http://www.umassmed.edu/research-home/

     

    The position includes opportunities for project and career development, interaction with a diverse, talented and collegial immunology community at UMMS.

     

    To apply for this position:

     

    Send your CV and the contact information for three references to: ann.rothstein@umassmed.edu

     

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