University of Massachusetts Medical School

  • Process Development Associate I- Upstream

    Minimum Salary US-MA-Mattapan
    Job Location 2 months ago(2 months ago)
    Requisition Number
    2018-31222
    # of Openings
    1
    Posted Date
    Day
    Shift
    Non Exempt
    Exempt/Non-Exempt Status
    Non Union Position-W25-Non Unit Classified
  • Overview

    MassBiologics

    GENERAL SUMMARY OF POSITION: 

     

    The Research Associate I is responsible for carrying out upstream cell culture process development activities supporting development of media and feed supplements, optimization and scale-up of cell culture processes for the production of monoclonal antibodies and technical transfer to manufacturing.  The Associate I will prepare, formulate, and filter cell culture basal media and reagents. Additionally, the Associate I will provide lab coverage during evenings, weekends, and holidays on a rotating basis, as required to support upstream development activities.  The incumbent will perform established assays and contribute to the development of new assays. 

    Responsibilities

    MAJOR RESPONSIBILITIES:

     

    • Maintains cell cultures in monolayer, shake flask, spinner flask and small-scale bench top bioreactor systems for the production of monoclonal antibodies.
    • Prepare experiments and maintain cell culture logs as required.
    • Performs analytical biochemistry and molecular biology assays as well as microscopy and other laboratory testing as required.
    • Keeps timely and accurate documentation records in notebooks, organize and report results.
    • Operates and maintains standard laboratory equipment and departmental specific laboratory equipment.
    • Analyzes data in Excel and DOE software, and provides accurate, concise data summaries
    • Ensures timely and accurate documentation in accordance with cGMP and MassBiologics' SOPs.  Contributes to the development of improved documentation processes.
    • Provides support for protocol writing, project summaries and technical reports.
    • Prepares written and oral reports for presentation to the supervisor(s) and development group.
    • Maintains reagent and equipment inventories, orders supplies and cleans laboratory areas, hoods and common equipment.
    • Exercises technical discretion in the design, execution and interpretation of experiments that contribute to project strategies within defined parameters. 
    • Perform additional job related duties as required.

    Qualifications

    • Requires a bachelor’s degree in Chemistry, Biochemistry, or related field with a minimum 0-2 years of relevant experience.
    • Hands on experience with antibody production in mammalian.
    • Ability to follow instructions precisely, recognize deviations, and recommend corrective action within scope of training.
    • Possesses strong attention to detail, ability to maintain accurate records and excellent proofreading skills.
    • Ability to troubleshoot within scope of training.
    • Strong critical thinking, time management and organizational skills. Demonstrated ability to manage and prioritize multiple projects and consistently meet deadlines.
    • Excellent written and verbal communication skills. Ability to communicate effectively with others.
    • Ability to work effectively both independently and as a member of a team.
    • Computer literate and proficient in MS Word, Excel and other relevant electronic systems.
    • Occasionally projects require flexibility in work schedule to meet business needs.

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