University of Massachusetts Medical School

  • Bioinformatician

    Minimum Salary US-MA-Worcester
    Job Location 2 months ago(5/3/2018 4:14 PM)
    Requisition Number
    # of Openings
    Posted Date
  • Overview


    In the Department of Molecular Cell & Cancer Biology of University of Massachusetts Medical School, we have developed a core team of accomplished computational biologists who work side-by-side with bench scientists to evaluate, select and develop algorithms and software pipelines to analyze, annotate, visualize and integrate various biological datasets, including those generated from high-throughput experiments such as ChIP-seq, ChIP-chip, RNA-seq, PAS-seq, iCLIP-seq, ATAC-Seq, miRNA-seq, exon sequencing, GUIDE-seq, single-cell sequencing, shRNA and gRNA screening, and CRISPR genome editing.  We are active contributors to the open-source open-development Bioconductor project. We have developed more than a dozen packages with various utilities, ranging from machine learning, peak calling, annotation, visualization, to gRNA design and evaluation.


    Under the direction of a member of the faculty, the Bioinformatician is responsible for the design, development, evaluation and iterative modification of a technical infrastructure to expedite the quantitative evaluation of data resulting from studies that are laboratory based.  The position will entail the establishment and maintenance of applicable in-house bioinformatics resources and interaction with individual lab members on customized research projects, as well independent projects that are solely computational. 


    Responsibilities include-

    • Develop novel algorithms and software tools for integrated data analysis and visualization of high-throughput dataset including next-generation sequencing data and proteomics data when existing software packages are not available or adequate
    • Enhance/Maintain Bioconductor packages developed in house
    • Collaborate closely with PIs and their lab members on research projects including evaluating, selecting, and implementing when needed the best of breed computational solutions for the analysis of biological data
    • Develop rapid prototypes and custom scripts for one-off type of analysis requests
    • Properly document the procedures used in computational analysis and provide summary report of results suitable for inclusion in manuscript and grant applications




    • Establish general bioinformatics resources for day-to-day use by members of the laboratory
    • In collaboration with a faculty member, generate customized programming solutions to improve user interaction with available bioinformatics resources
    • Assist in the implementation of programs for microarray analysis, high-throughput sequencing data analysis, cis regulatory motif identification, and multi-genome protein motif searches
    • Local establishment and customization of model organism genomic databases and tools for batch sequence analysis utilizing these resources
    • Interpret and present study results in support of laboratory members
    • Provide tabular and written summaries of approaches and analyses in a form suitable for inclusion in manuscripts or grant applications, as well as media for presentation at scientific meetings
    • Develop and implement custom bioinformatics programming solutions in collaboration with lab as necessary
    • Coordinate and collaborate with other research computing expertise at the Medical School as necessary
    • Participate in conference calls and data management meetings as needed
    • Perform other duties as required.





    • BS in computer science or a related discipline.   Previous work experience desired, but not required; candidates with advanced degrees will be considered.
    • Strong background in statistical methodology, software languages and computer systems (Perl, C++, R, MySQL, etc.)
    • Experience in writing basic search algorithms and the ability to generate new algorithms and programs for custom data manipulation and analysis
    • Excellent communication skills, both oral and written, and interpersonal skills necessary to interact with a wide range of individuals


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