Postdoctoral Fellow – Osteoimmunology (Bone biology and Immunology) Department of Rheumatology, University of Massachusetts Medical School
1. Bone Biology
- Design and carry out experiments to explore the molecular mechanisms through which various signaling pathways mediated by MAPKs, Casein kinases, cell metabolism, and ER stress control bone development and remodeling.
- Design and carry out experiments to understand how dysregulation of these pathways contribute to abnormal bone loss or formation, underlying osteoporosis, rheumatoid arthritis, heterotopic ossification, or Paget’s disease of bone.
- Design and carry out experiments to isolate ligament and/or skeletal stem cells in the pathological settings, including ankylosing spondylitis and osteochondroma.
2. Inflammation and innate immune responses
- Design and carry out experiments to explore how our novel regulators control inflammation-induced skeletal diseases such as rheumatoid arthritis and ankylosing spondylitis.
- Design and carry out experiments to understand how these regulators contribute to the pathogenesis of autoimmune diseases.
- Design and carry out experiments to develop potential therapeutics to human diseases by suppressing their activity or expression.
- Oversee technician and students working on related projects.
- Prepare oral presentations for program/department research in progress meetings, submit abstracts for poster and oral presentations at national/internationsl meetings.
- Write up research results for publication.
- PhD in Bone Biology, Immunology, Cell Biology, Molecular Biology or related discipline.
- Working knowledge of either bone biology or cellular immunology or both if possible.
- Hands-on laboratory experience in relevant methodologies, trouble-shooting technical problems, and data analysis skills are required.
- Experience in the following techniques preferred: handling/injecting/genotyping mice, DNA/RNA purification and quantification, qPCR, immunoblotting, enzyme-based immunoassays, histology for bone and/or soft tissues, and immunohistochemistry/immunofluorescent/confocal microscopy, preparation of lymphoid/myeloid cells, isolation and cell culture of lymphocyte/myeloid populations, multicolor flow cytometry, database comparisons.
- Outstanding organizational and time management skills, as well as the ability to work both independently and as part of a team in a fast-paced environment.
Find out more about the UMMS research community at http://www.umassmed.edu/research-home/
The position includes opportunities for project and career development, interaction with a diverse, talented and collegial immunology community at UMMS.
To apply for this position:
Send your CV and the contact information for three references to firstname.lastname@example.org