University of Massachusetts Medical School

  • Post Doctoral Associate

    Minimum Salary US-MA-Worcester
    Job Location 4 months ago(4/6/2018 3:19 PM)
    Requisition Number
    2018-30698
    # of Openings
    1
    Posted Date
    Day
    Shift
    Exempt
    Exempt/Non-Exempt Status
    Non Union Position-W63-Residents/Post Docs
  • Overview

    Postdoctoral Fellow – Osteoimmunology (Bone biology and Immunology) Department of Rheumatology, University of Massachusetts Medical School

    Responsibilities

    1. Bone Biology

    - Design and carry out experiments to explore the molecular mechanisms through which various signaling pathways mediated by MAPKs, Casein kinases, cell metabolism, and ER stress control bone development and remodeling. 

     

    - Design and carry out experiments to understand how dysregulation of these pathways contribute to abnormal bone loss or formation, underlying osteoporosis, rheumatoid arthritis, heterotopic ossification, or Paget’s disease of bone.

     

    - Design and carry out experiments to isolate ligament and/or skeletal stem cells in the pathological settings, including ankylosing spondylitis and osteochondroma.

     

    2. Inflammation and innate immune responses

    - Design and carry out experiments to explore how our novel regulators control inflammation-induced skeletal diseases such as rheumatoid arthritis and ankylosing spondylitis.

     

    - Design and carry out experiments to understand how these regulators contribute to the pathogenesis of autoimmune diseases.

     

    - Design and carry out experiments to develop potential therapeutics to human diseases by suppressing their activity or expression.

     

    3. Others

    - Oversee technician and students working on related projects.

     

    - Prepare oral presentations for program/department research in progress meetings, submit abstracts for poster and oral presentations at national/internationsl meetings.

     

    - Write up research results for publication.

    Qualifications

    REQUIRED QUALIFICATIONS:

    - PhD in Bone Biology, Immunology, Cell Biology, Molecular Biology or related discipline.

    - Working knowledge of either bone biology or cellular immunology or both if possible.

    - Hands-on laboratory experience in relevant methodologies, trouble-shooting technical problems, and data analysis skills are required.

    - Experience in the following techniques preferred: handling/injecting/genotyping mice, DNA/RNA purification and quantification, qPCR, immunoblotting, enzyme-based immunoassays, histology for bone and/or soft tissues, and immunohistochemistry/immunofluorescent/confocal microscopy, preparation of lymphoid/myeloid cells, isolation and cell culture of lymphocyte/myeloid populations, multicolor flow cytometry, database comparisons.

    - Outstanding organizational and time management skills, as well as the ability to work both independently and as part of a team in a fast-paced environment.

     

    Find out more about the UMMS research community at http://www.umassmed.edu/research-home/

     

    The position includes opportunities for project and career development, interaction with a diverse, talented and collegial immunology community at UMMS. 

     

    To apply for this position:

    Send your CV and the contact information for three references to jaehyuck.shim@umassmed.edu

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