GENERAL SUMMARY OF POSITION:
Positions are available in the Miller laboratory to investigate and extend the scope of bioluminescence for non-invasive imaging of specific biological processes and disease states in live cells and animals. Work in the lab is inherently multi-disciplinary and may include protein engineering, mouse imaging, culture of multiple cell lines, vector design, enzyme assays, chemical synthesis, and immunohistochemistry of tissues. Examples of recent lab efforts include bioluminescence imaging of gene expression and enzymatic activity in the brain [Nature Methods 11, 393 (2014); JACS 137, 8684 (2015); Angewandte Chemie 55, 4943 (2016)], detection of latent luciferase activity in fruit flies [PNAS 111, 4443 (2014)], and the development of new selective mutant luciferases and synthetic luciferin substrates [JACS 136, 13277 (2014); Angewandte Chemie 55, 4943 (2016)]. Motivated and inherently curious critical thinkers with experience in molecular biology, cell biology, biochemistry, neuroscience, and/or animal studies are particularly encouraged to apply.
Under the supervision of the Principal Investigator or designee
ENVIRONMENTAL WORKING CONDITIONS:
Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.